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Select item 50376871.

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Benedikt Grünewald, Jeffrey L. Bennett, Klaus V. Toyka, Claudia Sommer, Christian Geis

Int J Mol Sci. 2016 Sep; 17(9): 1407. Published online 2016 Aug 26. doi: 10.3390/ijms17091407

PMCID:: PMC5037687

Article PDF–1.7M

Select item 100992962.

Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability

Josefine Sell, Vahid Rahmati, Marin Kempfer, Sarosh R. Irani, Andreas Ritzau-Jost, Stefan Hallermann, Christian Geis

Neurol Neuroimmunol Neuroinflamm. 2023 May; 10(3): e200096. Published online 2023 Apr 7. doi: 10.1212/NXI.0000000000200096

PMCID:: PMC10099296

Article PDF–1.2M

Select item 85203893.

Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease

Carles Gaig, Yaroslau Compta, Anna Heidbreder, Maria J. Marti, Maarten J. Titulaer, Yvette Crijnen, Birgit Högl, Jan Lewerenz, María Elena Erro, Juan Carlos García-Moncó, Pasquale Nigro, Nicola Tambasco, Maja Patalong-Ogiewa, Marcus Erdler, Stefan Macher, Evelyn Berger-Sieczkowski, Romana Höftberger, Christian Geis, Markus Hutterer, Angela Milán-Tomás, Antonio Martin-Bastida, Lydia Lopez Manzanares, Sonia Quintas, Günter U. Höglinger, Nora Möhn, Florian Schöberl, Franziska S. Thaler, Gian Maria Asioli, Federica Provini, Giuseppe Plazzi, Koldo Berganzo, Morten Blaabjerg, Norbert Brüggemann, Tarsis Farias, Chen Fei Ng, Caroline Giordana, Alejandro Herrero-San Martín, Lucio Huebra, Katya Kotschet, Herburg Liendl, Teresa Montojo, Carlos Morata, Jesus Pérez-Pérez, Inmaculada Puertas, Thomas Seifert-Held, Caspar Seitz, Mateus Mistieri Simabukuro, Nieves Téllez, Javier Villacieros-Álvarez, Barbara Willekens, Lidia Sabater, Alex Iranzo, Joan Santamaria, Josep Dalmau, Francesc Graus

Neurology. 2021 Oct 5; 97(14): e1367–e1381. doi: 10.1212/WNL.0000000000012639

PMCID:: PMC8520389

Article PDF–901K

Select item 109694644.

Neurofilament Light Chain Concentration in Cerebrospinal Fluid in Children with Acute Nontraumatic Neurological Disorders

Tobias Geis, Svena Gutzeit, Sigrid Disse, Jens Kuhle, Sotiris Fouzas, Sven Wellmann

Children (Basel) 2024 Mar; 11(3): 360. Published online 2024 Mar 19. doi: 10.3390/children11030360

PMCID:: PMC10969464

Article PDF–1.0M

Select item 89349315.

One‐year results following PASCAL‐based or MitraClip‐based mitral valve transcatheter edge‐to‐edge repair

Nicolas A. Geis, Philipp Schlegel, Markus B. Heckmann, Hugo A. Katus, Norbert Frey, Patricia Crespo López, Philip W.J. Raake

ESC Heart Fail. 2022 Apr; 9(2): 853–865. Published online 2022 Feb 15. doi: 10.1002/ehf2.13849

PMCID:: PMC8934931

Article PDF–1.1M

Select item 89508736.

Impact of Percutaneous Mitral Valve Repair Using the MitraClip^TM System on Ventricular Arrhythmias and ICD Therapies

Nicolas A. Geis, Anna Göbbel, Michael M. Kreusser, Tobias Täger, Hugo A. Katus, Norbert Frey, Philipp Schlegel, Philip W. Raake

Life (Basel) 2022 Mar; 12(3): 344. Published online 2022 Feb 25. doi: 10.3390/life12030344

PMCID:: PMC8950873

Article PDF–1.1M

Select item 106198377.

Multiproxy analysis of Upper Palaeolithic lustrous gravels supports their anthropogenic use

Lila Geis, Francesco d’Errico, Fiona M. Jordan, Michel Brenet, Alain Queffelec

PLoS One. 2023; 18(11): e0291552. Published online 2023 Nov 1. doi: 10.1371/journal.pone.0291552

PMCID:: PMC10619837

Article PDF–13M

Select item 83935218.

PSMA-Targeting Radiopharmaceuticals for Prostate Cancer Therapy: Recent Developments and Future Perspectives

Mohamed El Fakiri, Nicolas M. Geis, Nawal Ayada, Matthias Eder, Ann-Christin Eder

Cancers (Basel) 2021 Aug; 13(16): 3967. Published online 2021 Aug 5. doi: 10.3390/cancers13163967

PMCID:: PMC8393521

Article PDF–1.4M

Select item 86195659.

Indocyanine Green for Leakage Control in Isolated Limb Perfusion

Isabel Zucal, Sebastian Geis, Lukas Prantl, Silke Haerteis, Thiha Aung

J Pers Med. 2021 Nov; 11(11): 1152. Published online 2021 Nov 5. doi: 10.3390/jpm11111152

PMCID:: PMC8619565

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Select item 776521910.

Broken Heartstrings—Post-Traumatic Stress Disorder and Psychological Burden after Acute Mitral Regurgitation Due to Chordae Tendineae Rupture

Anna Cranz, Anja Greinacher, Ede Nagy, Hans-Christoph Friederich, Hugo A. Katus, Nicolas Geis, Sven T. Pleger, Christoph Nikendei

J Clin Med. 2020 Dec; 9(12): 4048. Published online 2020 Dec 15. doi: 10.3390/jcm9124048

PMCID:: PMC7765219

Article PDF–354K

Select item 621358111.

Influence of Luting Materials on the Retention of Cemented Implant-Supported Crowns: An In Vitro Study

Ella A. Naumova, Felix Roth, Berit Geis, Christine Baulig, Wolfgang H. Arnold, Andree Piwowarczyk

Materials (Basel) 2018 Oct; 11(10): 1853. Published online 2018 Sep 28. doi: 10.3390/ma11101853

PMCID:: PMC6213581

Article PDF–792K

Select item 579901412.

A Validation Argument for a Simulation-based Training Course centered on Assessment, Recognition and Early Management of Pediatric Sepsis

Gary L. Geis, Derek S. Wheeler, Amy Bunger, Laura G. Militello, Regina G. Taylor, Jerome P. Bauer, Terri L. Byczkowski, Benjamin T. Kerrey, Mary D. Patterson

Simul Healthc. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Simul Healthc. 2018 Feb; 13(1): 16–26. doi: 10.1097/SIH.0000000000000271

PMCID:: PMC5799014

Article PDF–114K

Select item 479448413.

Editorial: Limbic Encephalitis: Autoimmune Impact on Inhibitory GABAergic Neuronal Pathways in Temporal Lobe Epilepsy

Nico Melzer, Christian Geis, Sven G. Meuth

Front Neurol. 2016; 7: 36. Published online 2016 Mar 17. doi: 10.3389/fneur.2016.00036

PMCID:: PMC4794484

Article PDF–104K

Select item 1021960014.

Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy

Ha-Yeun Chung, Jonathan Wickel, Nina Hahn, Nils Mein, Meike Schwarzbrunn, Philipp Koch, Mihai Ceanga, Holger Haselmann, Carolin Baade-Büttner, Nikolai von Stackelberg, Nina Hempel, Lars Schmidl, Marco Groth, Nico Andreas, Juliane Götze, Sina M. Coldewey, Michael Bauer, Christian Mawrin, Justina Dargvainiene, Frank Leypoldt, Stephan Steinke, Zhao-Qi Wang, Michael Hust, Christian Geis

Sci Adv. 2023 May; 9(21): eabq7806. Published online 2023 May 26. doi: 10.1126/sciadv.abq7806

PMCID:: PMC10219600

Article PDF–2.5M

Select item 1015118115.

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Stephan Steinke, Toni Kirmann, Eleonora A Loi, Jana Nerlich, Iron Weichard, Philipp Kuhn, Torsten Bullmann, Andreas Ritzau-Jost, Filiz Sila Rizalar, Harald Prüss, Volker Haucke, Christian Geis, Michael Hust, Stefan Hallermann

Brain. 2023 May; 146(5): 1812–1820. Published online 2023 Mar 3. doi: 10.1093/brain/awac497

PMCID:: PMC10151181

Article PDF–764K

Select item 950627316.

Long-Term Patency of Venous Conduits Targeting the Right Coronary Artery System—Single Is Superior to Sequential bypass Grafting

Rawa Arif, Aglaia Warninck, Mina Farag, Wiebke Sommer, Florian Leuschner, Norbert Frey, Matthias Karck, Gregor Warnecke, Nicolas A. Geis

J Cardiovasc Dev Dis. 2022 Sep; 9(9): 285. Published online 2022 Aug 26. doi: 10.3390/jcdd9090285

PMCID:: PMC9506273

Article PDF–1.1M

Select item 513387917.

Prostate Specific Antigen (PSA) as Predicting Marker for Clinical Outcome and Evaluation of Early Toxicity Rate after High-Dose Rate Brachytherapy (HDR-BT) in Combination with Additional External Beam Radiation Therapy (EBRT) for High Risk Prostate Cancer

Thorsten H. Ecke, Hui-Juan Huang-Tiel, Klaus Golka, Silvia Selinski, Berit Christine Geis, Stephan Koswig, Katrin Bathe, Steffen Hallmann, Holger Gerullis

Int J Mol Sci. 2016 Nov; 17(11): 1879. Published online 2016 Nov 10. doi: 10.3390/ijms17111879

PMCID:: PMC5133879

Article PDF–815K

Select item 849733618.

PASCAL‐based mitral valve repair in an all‐comer population: acute and mid‐term clinical results

Philipp Schlegel, Patricia Crespo López, Michael M. Kreusser, Hugo A. Katus, Norbert Frey, Nicolas A. Geis, Philip W.J. Raake

ESC Heart Fail. 2021 Oct; 8(5): 3530–3538. Published online 2021 Aug 27. doi: 10.1002/ehf2.13569

PMCID:: PMC8497336

Article PDF–959K

Select item 743572519.

Properties of Styrene-Maleic Anhydride Copolymer Compatibilized Polyamide 66/Poly (Phenylene Ether) Blends: Effect of Blend Ratio and Compatibilizer Content

Alper Aksit, Nico Geis, Merve Aksit, Volker Altstädt

Materials (Basel) 2020 Aug; 13(15): 3400. Published online 2020 Jul 31. doi: 10.3390/ma13153400

PMCID:: PMC7435725

Article PDF–8.5M

Select item 692488120.

Effect of Acute Illness on Contact Patterns, Malawi, 2017

Judith R. Glynn, Estelle McLean, Jullita Malava, Albert Dube, Cynthia Katundu, Amelia C. Crampin, Steffen Geis

Emerg Infect Dis. 2020 Jan; 26(1): 44–50. doi: 10.3201/eid2601.181539

PMCID:: PMC6924881

Article PDF–1.0M

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PMC Images search for GEIS

Fig. 4

Various functions encoded by GEIs of the same family. Modified Artemis Comparison Tool view of four GEIs of the same family: ICEHin1056, clc, ICEHpaT3T1 and PAPI. Homologous sequences (minimum cut-off=50) are indicated by grey lines joining regions of the four GEIs. Gene modules homologous in all shown GEIs are represented by white boxes, and modules specific for individual GEIs by black boxes. The figure shows that depending on the composition of gene modules, members of the same family of GEIs can promote survival of pathogenic (ICEHin1056, ICEHpaT3T1, PAPI of Haemophilus influenzae, Haemophilus parainfluenzae and Pseudomonas aeruginosa, respectively) as well as environmental (clc of Pseudomonas sp. B13) bacteria. ATB resist., antibiotics resistance; T4SS, type IV secretion system; Integr., integration.

Genomic islands: tools of bacterial horizontal gene transfer and evolution

FEMS Microbiol Rev. 2009 Mar;33(2):376-393.
Fig. 1

General features of GEIs. GEIs are relatively large segments of DNA whose nucleotide characteristics often differ from the rest of the chromosome. GEIs are often inserted at tRNA genes and flanked by DR. GEIs typically harbour genes encoding factors involved in genetic mobility, such as integrases, transposases and insertion sequences (IS). According to their gene content, GEIs can be described as pathogenicity, symbiosis, metabolic, fitness or resistance islands.

Genomic islands: tools of bacterial horizontal gene transfer and evolution

FEMS Microbiol Rev. 2009 Mar;33(2):376-393.
Fig. 2

Disease-free survival analysis according to Fletcher’s risk groups in 162 patients registered in GEIS

GEIS 2013 guidelines for gastrointestinal sarcomas (GIST)

Cancer Chemother Pharmacol. 2014;74(5):883-898.
Fig. 1

Relapse-free survival analysis according to Fletcher’s risk groups in 162 patients registered in GEIS

GEIS 2013 guidelines for gastrointestinal sarcomas (GIST)

Cancer Chemother Pharmacol. 2014;74(5):883-898.